1-ethyl-2-[[3-(4-sulphonatobutyl)-3H-benzothiazol-2-ylidene]methyl]quinolinium

  • Name: 1-ethyl-2-[[3-(4-sulphonatobutyl)-3H-benzothiazol-2-ylidene]methyl]quinolinium
  • CAS: 63912-44-7
  • Purity: 99%
Inquiry

Details

Manufacturer supply 1-ethyl-2-[[3-(4-sulphonatobutyl)-3H-benzothiazol-2-ylidene]methyl]quinolinium 63912-44-7 with sufficient stock and high standard

  • Molecular Formula: C23H24 N2 O3 S2
  • Molecular Weight: 440.5783
  • Boiling Point: °Cat760mmHg 
  • Flash Point: °C 
  • PSA： 120.35000 
  • Density: g/cm3 
  • LogP: 4.24400 

1-ethyl-2-[[3-(4-sulphonatobutyl)-3H-benzothiazol-2-ylidene]methyl]quinolinium(Cas 63912-44-7) Usage

Structure

Quinolinium core with an ethyl group at the first position, a benzothiazolylidene-methyl group at the second position, and a sulphonatobutyl substituent

Function

Fluorescent dye used to detect and visualize amyloid fibrils in biochemistry and neuroscience research

Relevance

Implicated in neurodegenerative diseases such as Alzheimer's and Parkinson's

Property

Exhibits strong fluorescence upon binding to amyloid structures

Application

Valuable tool for studying and diagnosing amyloid-related diseases, potential use in drug development and screening for compounds that can inhibit amyloid formation.

General Description

1-Ethyl-2-[[3-(4-sulphonatobutyl)-3H-benzothiazol-2-ylidene]methyl]quinolinium, also known as Thioflavin T, is a fluorescent dye commonly used in biochemistry and neuroscience research to detect and visualize amyloid fibrils, which are implicated in a variety of neurodegenerative diseases such as Alzheimer's and Parkinson's. The molecule contains a quinolinium core with an ethyl group at the first position and a benzothiazolylidene-methyl group at the second position, along with a sulphonatobutyl substituent. Thioflavin T exhibits strong fluorescence upon binding to amyloid structures, making it a valuable tool for studying and diagnosing amyloid-related diseases. Additionally, it has potential applications in drug development and screening for compounds that can inhibit amyloid formation.

InChI:InChI=1/C23H24N2O3S2/c1-2-24-19(14-13-18-9-3-4-10-20(18)24)17-23-25(15-7-8-16-30(26,27)28)21-11-5-6-12-22(21)29-23/h3-6,9-14,17H,2,7-8,15-16H2,1H3

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