Fmoc-O-tert-Butyl-L-threonine

  • Name: Fmoc-O-tert-Butyl-L-threonine
  • CAS: 71989-35-0
  • Purity: 99%
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What is the Fmoc-O-tert-Butyl-L-threonine ?

Fmoc-O-tert-Butyl-L-threonine is white to light yellow crystal powder, while it's Molecular Formula is C23H27NO5. Used in Peptide Synthesis:
Fmoc-O-tert-Butyl-L-threonine is used as a protected amino acid building block for the synthesis of peptides and proteins. The Fmoc group serves as a protecting group for the amino group, while the tert-butyl group protects the hydroxyl group, preventing unwanted side reactions during the assembly process. This allows for the stepwise and controlled formation of peptide bonds in solid-phase peptide synthesis.
Used in Organic Synthesis:
Fmoc-O-tert-Butyl-L-threonine can also be used as a chiral building block in organic synthesis for the preparation of various pharmaceuticals, agrochemicals, and other biologically active compounds. The presence of the L-threonine chiral center and the protecting groups make it a versatile intermediate for the synthesis of enantiomerically pure compounds.
Used in Research and Development:
Fmoc-O-tert-Butyl-L-threonine is utilized in research and development for the study of peptide synthesis methods, the development of new protecting group strategies, and the investigation of the properties and applications of protected amino acids. It can also be used as a reference compound for analytical methods and quality control in the synthesis of peptides and related compounds.

What is the CAS number for Fmoc-O-tert-Butyl-L-threonine ?

The CAS number of Fmoc-O-tert-Butyl-L-threonine is 71989-35-0.

More information of Fmoc-O-tert-Butyl-L-threonine 71989-35-0 are:

Synonyms

(2S,3R)-2-(((9-Fluorenylmethoxy)carbonyl)amino)-3-(tert-butoxy)butanoicacid;(2S,3R)-3-tert-Butoxy-2-[[[[9H-fluoren-9-yl]methoxy]carbonyl]amino)butanoicacid;N-(9-Fluorenylmethoxycarbonyl)-O-tert-butylthreonine;Fmoc-Thr(tBu)-OH;L-Threonine,O-(1,1-dimethylethyl)-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-;

CAS?Number

71989-35-0

Molecular Formula

C23H27NO5

Molecular Weight

397.471

Density

1.197 g/cm3

Melting Point

131-134 °C

Boiling Point

581.7 °C at 760 mmHg

Flash Point

305.6 °C

HS CODE

29242990

PSA

84.86000

LogP

4.57280

Pka

3.42±0.10(Predicted)

What is Fmoc-O-tert-Butyl-L-threonine (71989-35-0) used for?

Fmoc-O-tert-Butyl-L-threonine, also known as N-(9-Fluorenylmethoxycarbonyl)-O-tert-butyl-L-threonine, is a synthetic derivative of the naturally occurring amino acid L-threonine. It is characterized by the presence of a 9-fluorenylmethoxycarbonyl (Fmoc) protecting group and a tert-butyl (t-Bu) protecting group on the hydroxyl group. Fmoc-O-tert-Butyl-L-threonine is a white to light yellow crystalline powder and is commonly used in the field of organic synthesis and peptide chemistry.

InChI:InChI=1/C23H27NO5/c1-14(29-23(2,3)4)20(21(25)26)24-22(27)28-13-19-17-11-7-5-9-15(17)16-10-6-8-12-18(16)19/h5-12,14,19-20H,13H2,1-4H3,(H,24,27)(H,25,26)/p-1/t14-,20+/m1/s1

Articles related to Fmoc-O-tert-Butyl-L-threonine:

Article

Source

A Fmoc - Thr (tBu) - OH preparation method (by machine translation)

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Paragraph 0031-0038, (2019/02/04)

A one-pot procedure for the preparation of N-9-fluorenylmethyloxycarbonyl- α-amino diazoketones from α-amino acids

Siciliano, Carlo,De Marco, Rosaria,Guidi, Ludovica Evelin,Spinella, Mariagiovanna,Liguori, Angelo

, p. 10575 - 10582 (2013/02/22)

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