Details
Offer Chemical Raw Material 2-Chlorophenethylalcohol 19819-95-5 In Stock
- Molecular Formula: C8H9ClO
- Molecular Weight: 156.612
- Appearance/Colour: clear colorless liquid
- Vapor Pressure: 0.0435mmHg at 25°C
- Refractive Index: n20/D 1.551(lit.)
- Boiling Point: 227.5 °C at 760 mmHg
- PKA: 14.72±0.10(Predicted)
- Flash Point: 101.1 °C
- PSA： 20.23000
- Density: 1.189 g/cm3
- LogP: 1.87480
2-Chlorophenethylalcohol(Cas 19819-95-5) Usage
InChI:InChI=1/C8H9ClO/c9-8-4-2-1-3-7(8)5-6-10/h1-4,10H,5-6H2
19819-95-5 Relevant articles
Para-Selective C-H Borylation of Common Arene Building Blocks Enabled by Ion-Pairing with a Bulky Countercation
Mihai, Madalina T.,Williams, Benjamin D.,Phipps, Robert J.
supporting information, p. 15477 - 15482 (2019/10/11)
The selective functionalization of C-H b...
Dihydroxy pyrimidine compound and use thereof
-
Paragraph 0026-0028, (2019/07/04)
The invention provides a dihydroxy pyrim...
Antiproliferative activity and SARs of caffeic acid esters with mono-substituted phenylethanols moiety
Xie, Jin,Yang, Fengzhi,Zhang, Man,Lam, Celine,Qiao, Yixue,Xiao, Jia,Zhang, Dongdong,Ge, Yuxuan,Fu, Lei,Xie, Dongsheng
, p. 131 - 134 (2016/12/27)
A series of CAPE derivatives with mono-s...
Discovery, synthesis, and structure-activity relations of 3,4-dihydro-1H-spiro(naphthalene-2,2′-piperidin)-1-ones as potassium-competitive acid blockers
Imaeda, Toshihiro,Ono, Koji,Nakai, Kazuo,Hori, Yasunobu,Matsukawa, Jun,Takagi, Terufumi,Fujioka, Yasushi,Tarui, Naoki,Kondo, Mitsuyo,Imanishi, Akio,Inatomi, Nobuhiro,Kajino, Masahiro,Itoh, Fumio,Nishida, Haruyuki
, p. 3719 - 3735 (2017/06/13)
With the aim to discover a gastric antis...
19819-95-5 Process route
-
-
2444-36-2
2'-chloro-benzeneacetic acid
-
-
19819-95-5
2-(2-chlorophenyl)-1-ethanol
| Conditions | Yield |
|---|---|
|
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
1.) RT, 0.5 h, 2.) reflux, 2 h;
|
88%
|
|
With
lithium aluminum hydride;
In
diethyl ether;
at 35 ℃;
for 2h;
|
87%
|
|
With
tin(II) trifluoromethanesulfonate; tris(2,4-pentanedionato)ruthenium(III); hydrogen; [2-((diphenylphospino)methyl)-2-methyl-1,3-propanediyl]bis[diphenylphosphine];
In
water; toluene;
at 165 ℃;
for 48h;
under 45004.5 Torr;
Autoclave;
|
87%
|
|
With
tetrahydrofuran; borane;
at 0 - 20 ℃;
for 2h;
Inert atmosphere;
|
83%
|
|
With
lithium aluminium tetrahydride;
|
|
|
With
lithium aluminium tetrahydride;
In
diethyl ether;
at 0 ℃;
for 0.333333h;
|
|
|
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
at 0 ℃;
for 4.5h;
Reflux;
|
|
|
Multi-step reaction
with
2
steps
1: thionyl chloride / 3 h / 0 - 20 °C
2: lithium aluminium tetrahydride / tetrahydrofuran / 4.5 h / 0 - 20 °C / Inert atmosphere
With
lithium aluminium tetrahydride; thionyl chloride;
In
tetrahydrofuran;
|
|
|
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
at 0 - 30 ℃;
|
18.3g
|
-
-
2039-87-4,107830-52-4,26125-41-7
2-chlorostyrene
-
-
13524-04-4,120466-66-2,132437-66-2,131864-71-6
(S)-1-(2'-chlorophenyl)ethanol
-
-
19819-95-5
2-(2-chlorophenyl)-1-ethanol
-
-
13524-04-4,131864-71-6,132437-66-2,120466-66-2
(R)-1-(o-chlorophenyl)ethanol
| Conditions | Yield |
|---|---|
|
2-chlorostyrene;
With
benzo[1,3,2]dioxaborole;
rhodium complex 8;
In
toluene;
at 20 ℃;
for 2h;
With
sodium hydroxide; water; dihydrogen peroxide;
In
toluene;
at 20 ℃;
for 2h;
Title compound not separated from byproducts;
|
|
|
2-chlorostyrene;
With
bis(1,5-cyclooctadiene)rhodium(I) tetrafluoroborate; (1R,2R)-1,2-bis(di[2-furyl]phosphanyl)cyclohexane; benzo[1,3,2]dioxaborole;
In
1,2-dimethoxyethane; toluene;
at -75 ℃;
for 1h;
With
potassium hydroxide; dihydrogen peroxide;
In
1,2-dimethoxyethane;
Title compound not separated from byproducts;
|
|
|
With
pinacol borane; 4 A molecular sieve;
Rh(2,5-norbornadiene)2BF4;
In
1,2-dimethoxyethane;
at 20 ℃;
for 12h;
Title compound not separated from byproducts.;
|
19819-95-5 Upstream products
-
26059-40-5
2-(2-iodophenyl)ethan-1-ol
-
2444-36-2
2'-chloro-benzeneacetic acid
-
40061-54-9
2-chlorophenylacetic acid ethyl ester
-
2039-87-4
2-chlorostyrene
19819-95-5 Downstream products
-
1005-06-7
2-chlorophenylethyl chloride
-
30953-58-3
o-Chlor-β-phenethylhydrazin
-
16793-91-2
1-(2-bromoethyl)-2-chlorobenzene
-
178685-04-6
1-(2-iodoethyl)-2-chlorobenzene
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